Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34822784
2.
The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes.
Proc Natl Acad Sci U S A
; 119(24): e2201103119, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35671422
3.
Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease.
Proc Natl Acad Sci U S A
; 118(10)2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33653950
4.
Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease.
Proc Natl Acad Sci U S A
; 118(50)2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34893539
5.
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Nat Chem Biol
; 16(3): 240-249, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32080630
6.
Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Nat Chem Biol
; 15(5): 489-498, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30992568
7.
Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models.
Annu Rev Pharmacol Toxicol
; 56: 535-59, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26738479
8.
Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.
Proc Natl Acad Sci U S A
; 113(16): 4524-9, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27071102
9.
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.
Mol Pharmacol
; 93(6): 645-656, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29695609
10.
An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.
J Biol Chem
; 291(17): 8862-75, 2016 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26826123
11.
Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?
Front Pharmacol
; 13: 893422, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35645791
12.
M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.
Sci Signal
; 15(760): eabm3720, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36378750
13.
Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia.
Mol Pharmacol
; 79(5): 874-85, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21321061
14.
Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor.
J Pharmacol Exp Ther
; 334(3): 795-808, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20507928
15.
M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?
Adv Pharmacol
; 88: 277-310, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32416870
16.
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.
Front Pharmacol
; 11: 606656, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33584282
17.
Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor.
Mol Pharmacol
; 76(6): 1302-13, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19737913
18.
The use of chemogenetic approaches to study the physiological roles of muscarinic acetylcholine receptors in the central nervous system.
Neuropharmacology
; 136(Pt C): 421-426, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29191752
19.
Alterations in neuronal metabolism contribute to the pathogenesis of prion disease.
Cell Death Differ
; 25(8): 1408-1425, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29915278
20.
DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo.
ACS Pharmacol Transl Sci
; 1(1): 61-72, 2018 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30868140